Abstracts & Commentary
Intervention study links air quality to cardiovascular risk factors. Could a simple indoor filtration system yield significant health benefits?
Recent evidence demonstrates a clear association between proton pump inhibitors and kidney disease.
New evidence supports the use of melatonin as a safe, low-cost intervention to improve not only sleep quality, but quality of life, in women with breast cancer.
Research supports current evidence regarding the health effects of phosphate and raises questions about product labeling.
The serendipitous discovery that grapefruit juice could dramatically increase the bioavailability of orally administered medications resulted from the findings of a 1989 clinical trial on the pharmacodynamics of felodipine. Grapefruit juice is now estimated to pose a nutrient-drug interaction with more than 85 different medications. The primary mechanism of this interaction is inhibition of cytochrome P450 3A4 (CYP3A4), but grapefruit juice also inhibits organic anion-transporter polypeptides (OATPs). These mechanisms can increase bioavailability, decrease bioavailability, or reduce the metabolic activation of certain medications. Many commonly prescribed drugs interact with grapefruit juice, and these interactions can produce clinically significant effects. Consumption of a single glass of juice is sufficient to alter drug metabolism, and the effect can last as long as 3 days. Practical implications of grapefruit juice-drug interactions are reviewed here.
Leading integrative health expert, Russell Jaffe, MD, PhD, CCN, describes how clinicians can identify and treat inflammatory issues long before illness sets in. He also describes ways to reverse chronic inflammation including diet, lifestyle, and utilization of the C Cleanse technique.