Colorectal Cancer Risk Reduction Using Metformin
Second part of a 2-part series discussing whether metformin has a place in natural medicine
By Davis W. Lamson, ND
About the Author
After a career in chemistry research and university instructing, Davis W. Lamson, ND, enrolled in the first naturopathic medicine class at Bastyr University, receiving the doctorate in 1982. Lamson practices at Tahoma Clinic in Tukwila, Washington, with particular interests in autoimmunity and cancer. He has published more than 35 research and review papers on the subjects of hepatitis C, controling MRSA, stimulating immune function, emphysema, autism, diabetes, gastroesophageal reflux, kidney failure, autoimmunity, and various cancer-related topics. Lamson received the 2004 Bastyr University Distinguished Alumnus Award and the 2005 President’s Award of the Oncology Association of Naturopathic Physicians on its founding. In 2015, he received the Lifetime Achievement Award of that association.
Note: This is the second in a 2-part series on whether metformin has a place in natural medicine. Find the first installment here.
Study Medication and Dosage
These results stand out for two reasons: first, these were nondiabetic patients; and second, these patients received relatively small doses of metformin.
Is metformin natural medicine?
- Tomimoto A, Endo H, Sugiyama M, et al. Metformin suppresses intestinal polyp growth in ApcMin/+ mice. Cancer Sci. 2008;99(11):2136-2141.
- Hosono K, Endo H, Takahashi H, et al. Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase. Mol Carcinog. 2010;49(7):662-671.
- Das D, Arber N, Jankowski JA. Chemoprevention of colorectal cancer. Digestion. 2007;76(1):51-67.
- Meyskens FL, McLaren CE, Pelot D, et al. Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila). 2008;1(1):32-38.
- Pettan-Brewer C, Morton J, Mangalindan R, Ladiges W. Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet. Pathobiol Aging Age Relat Dis. 2011;1.
- Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654.
- Zhang J, Cao H, Zhang B, et al. Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling. J Cell Mol Med. 2013;17(11):1484-1493.
- McCreight LJ, Bailey CJ, Pearson ER. Metformin and the gastrointestinal tract. Diabetologia. 2016;59(3):426-435.
- Bouchoucha M, Uzzan B, Cohen R. Metformin and digestive disorders. Diabetes Metab. 2011;37(2):90-96.