Kyowa Hakko USA, Inc. is the North American sales office for KYOWA HAKKO BIO CO., LTD, a world leader in the research and manufacturing of quality-assured amino acids and related compounds. Backed by 65+ years of manufacturing expertise, all Kyowa ingredients meet the most demanding quality assurance standards for efficacy, safety, purity and consistency.

Pioneers in the development and application of a patented fermentation technology used in the manufacturing of all Kyowa ingredients, many of our amino acids and related compounds have usage and IP patents as well.

Kyowa's ingredients are backed by a long-standing commitment to science that includes partnerships with top research facilities around the globe, as well as our on-site research and development staff. Health claims for our products are based on decades of research that have been designed to substantiate the unique and specific health benefits of individual ingredients. With the majority of research findings published in peer-reviewed journals over the years, Kyowa’s research and development staff continue to pursue new opportunities.

Key branded ingredients include:

Setria® is a clinically studied form of glutathione that, when taken orally, has been shown to replenish the body's reserves, which may be depleted as a result of poor lifestyle choices, stress or natural aging. Called the "master antioxidant," glutathione helps protect cells in the body from the damaging effects of oxidative stress and toxins. Setria Glutathione is manufactured through a patented fermentation and patent pending for increasing natural killer (NK) cell activity, is pure, vegetarian and allergen-free.

A published study on Setria® Glutathione in the European Journal of Nutrition, May 2014 shows, for the first time, that daily consumption of glutathione is effective at increasing glutathione blood levels. This long-term, randomized, double-blinded, placebo-controlled study puts to rest the long-standing debate on the efficacy of oral glutathione.

The study performed on 54 healthy adults (mean age 46 years) showed that blood levels of glutathione increased after one, three and six months vs. baseline at doses of both 250 mg/day and 1,000 mg/day. At six months, mean blood glutathione levels along with various immune markers were shown to have increased 30-35 percent in the high-dose group, and 17-29 percent in the low dose. Natural killer cytotoxicity increased two-fold in the high-dose group versus placebo at 3 months. A reduction in oxidative stress in both glutathione dose groups was indicated by decreases in the oxidized to reduced glutathione ratio in whole blood. Glutathione levels were shown to return to baseline after a 1-month washout period.

Cognizin® is a proprietary form of citicoline, a potent brain-health nutrient. Cognizin has been tested in numerous clinical trials to support mental energy, focus and attention. Developed using a patented fermentation process, Cognizin is a pure, allergen-free GRAS ingredient that’s stable and effective.

Key studies on Cognizin include a 2008 study on healthy middle-aged adults (2008 Silveri). Researchers using the latest brain scanning technology at the Harvard-associated Brain Imaging Center at McLean Hospital, observed increases in brain activity among people who had taken 500 mg Cognizin for six weeks -- particularly when they performed tasks that required sustained attention or memory. The study reported that Cognizin® speeds up the formation of brain membranes by 26%, and restores brain energy by 14%.

In another study on middle-aged women (2012 McGlade), researchers at the Brain Institute at the University of Utah found that 250 mg of Cognizin improved attentional focus and inhibition. Women receiving either the low or high dose of Cognizin citicoline produced fewer commission errors on the CPT-II compared to the placebo group. Specifically, individuals in the two Cognizin citicoline supplemented groups made fewer errors when responding to non-target stimuli.

Sustamine® L-Alanyl-L-Glutamine is an excellent choice for use in clinical nutrition because it does not have the problems of poor stability and low solubility that are associated with free-glutamine. Glutamine begins to degrade when mixed with liquids, but Sustamine® is a unique dipeptide form of glutamine that’s been designed for maximum stability. This means that patients will get the amount listed on the label when they add it to water or their favorite beverage. Sustamine is also tasteless, colorless, odorless and dissolves completely in hot or cold liquids – so there is no gritty texture. Sustamine is also pure, vegetarian and allergen-free.

Pantesin® is a branded form of Pantethine, a derivative of vitamin B5, that helps the body maintain a healthy cholesterol ratio. Pantesin® is the only pantethine backed by 35+ years of research. With numerous studies supporting Pantesin’s effectiveness in high-risk subjects, current research (2011 Rumberger) shows that it is also effective for low to medium risk individuals.

T: 800.596.9252

Kyowa Hakko USA

New York Office

600 Third Avenue, 19th Floor

New York, NY 10016