Peer-Reviewed Articles

A Hydrolyzed Casein Standardized to Lactotripeptides for Support of Vascular Health

by Ginny Bank, MS
Lactotripeptides (LTPs) found in fermented milk have been shown to have potential antihypertensive properties by acting as angiotensin-converting enzyme (ACE) inhibitors. A standardized LTP product, with levels of LTP higher than what is available from dairy products, has also been shown in both in vitro and animal models to induce nitric oxide (NO) production and attenuate atherosclerosis. Clinical research has confirmed that LTP can promote vasodilation, improve endothelial function, and mitigate arterial stiffness in prehypertensive and hypertensive subjects. In this review of published research on the standardized LTP product, we discuss its established mechanisms of action and the randomized placebo-controlled clinical trials that document its potential beneficial effects on cardiovascular health.

Recognizing Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA)

by Tina Kaczor, ND, FABNO
Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA) is a relatively new entity introduced in 2011. Diagnosis of ASIA is based on major and minor criteria encompassing generalized signs and symptoms such as persistent fatigue, cognitive difficulties, neurological deficits, myalgias/arthralgias, and dry mouth. As the name implies, an immune adjuvant is requisite, although the adjuvant itself may or may not be identified. ASIA is thought to be a rare entity, which makes the identification and study of those affected challenging. Knowledge of ASIA may help clinicians identify patients with underlying immune dysregulation.

Abstracts & Commentary

Colorectal Cancer Risk Reduction Using Metformin

by Davis W. Lamson, ND
Last month we learned of metformin’s anticancer benefits in breast cancer. This month we review the evidence for its potential to prevent colorectal cancer. And again we ask, “What place does metformin have in natural medicine?”

Acetaminophen and Risk of Behavioral Problems in Children

by Michael T. Murray, ND
Associations between prenatal use of acetaminophen and behavioral problems in children adds to concerns about the safety of what is widely considered to be a benign over-the-counter remedy for pain and fever.

Benefits of Elderberry for Symptoms of Common Cold in Air Travelers

by Michael Traub, ND, DHANP, FABNO
In this placebo-controlled study, elderberry extract reduced symptoms and duration of common colds related to air travel, but the quality of the study raises some concerns.

Self-Care with Acupressure for Cancer-Related Fatigue

by Rebecca Lovejoy, ND, LAc
Acupressure significantly improved sleep quality and quality of life measures in women with persistent cancer-related fatigue in a recent randomized clinical trial.

Diet for Prostate Cancer Survivors

by Jacob Schor, ND, FABNO
Study analyzing associations between consumption of various sources of protein and recurrence of prostate cancer does not yield exciting new findings, but there are a few take-home messages.

Vitamin D in Miscarriage Prevention

by Jennifer Fitzgerald, ND
Randomized controlled trial shows vitamin D supplementation reduces pregnancy losses and provides clues to the mechanism of action.

Topical EGCG for Radiation Dermatitis

by Kirsten West, ND
Epigallocatechin-3-gallate (EGCG), a polyphenol abundant in green tea, appears to soothe the red, burning, painful, itchy skin associated with radiation therapy.