Abstracts & Commentary
New evidence supports the use of melatonin as a safe, low-cost intervention to improve not only sleep quality, but quality of life, in women with breast cancer.
Intervention study links air quality to cardiovascular risk factors. Could a simple indoor filtration system yield significant health benefits?
Research supports current evidence regarding the health effects of phosphate and raises questions about product labeling.
Recent evidence demonstrates a clear association between proton pump inhibitors and kidney disease.
The serendipitous discovery that grapefruit juice could dramatically increase the bioavailability of orally administered medications resulted from the findings of a 1989 clinical trial on the pharmacodynamics of felodipine. Grapefruit juice is now estimated to pose a nutrient-drug interaction with more than 85 different medications. The primary mechanism of this interaction is inhibition of cytochrome P450 3A4 (CYP3A4), but grapefruit juice also inhibits organic anion-transporter polypeptides (OATPs). These mechanisms can increase bioavailability, decrease bioavailability, or reduce the metabolic activation of certain medications. Many commonly prescribed drugs interact with grapefruit juice, and these interactions can produce clinically significant effects. Consumption of a single glass of juice is sufficient to alter drug metabolism, and the effect can last as long as 3 days. Practical implications of grapefruit juice-drug interactions are reviewed here.
In the 1980s national policies directed at lowering fat consumption emerged. One of the many reasons for recommending fat restriction was the apparent association between high dietary fat and breast cancer incidence—an association based on epidemiological and case control data. We now know that epidemiological studies and case controlled studies are poor predictors of how dietary patterns influence cancer risk. Furthermore, newer, prospective studies no longer support the association between dietary fat and breast cancer except in a small subset of cancers.
Leading integrative health expert, Russell Jaffe, MD, PhD, CCN, describes how clinicians can identify and treat inflammatory issues long before illness sets in. He also describes ways to reverse chronic inflammation including diet, lifestyle, and utilization of the C Cleanse technique.
In this sponsored podcast integrative health expert Russell Jaffe, MD, PhD, CCN, describes a comprehensive approach to identifying immune dysfunction long before illness sets in. He also provides advice regarding diet, lifestyle, and dietary supplements. Jaffe explains why choice is far more significant than genetics and how to counsel patients about reducing immune burden.