Abstracts & Commentary
There have been many studies that have shown chemotherapy related cognitive impairment (CRCI), otherwise known as "chemo brain" is a sequela of chemotherapy in breast cancer survivors. This study is the first to demonstrate cognitive impairment can be significant two decades after receiving a chemotherapy regimen, in this case CMF. The permanence of these symptoms for some patients should prompt us to prioritize brain recovery after chemotherapy treatment.
One hundred twenty patients with polycystic ovarian syndrome (PCOS) and 14-16 months of infertility were studied in this randomized, controlled clinical trial. In the study, fifty percent of the patients who received metformin restored spontaneous ovulation, and 18.3% of these achieved pregnancy.
In this prospective cohort study, 40,757 people aged 29 to 69, who were part of the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition, were followed from baseline in 1992 to 1996 until 2004. Computerized dietary history questionnaires administered by trained interviewers were used to assess participant food consumption patterns. During a median of 11 years in which cohort participants were followed, 606 coronary heart disease events and 1135 deaths from all causes occurred. Eating large quantities of fried foods was not associated with a significant change in either disease or mortality risk.
In the Alpine area of Italy there is a long tradition of phytothermotherapy, or immersion of the patient's body in fermenting freshly mown grass, to treat certain rheumatic diseases, including OA. Known as "hay baths,"Â this treatment consists of 20-minute daily immersions for 10 days in warm grass. This randomized, controlled clinical trial tested the effectiveness of these "hay baths."
Interviews with Experts
Long-term use of oral contraceptives (OCs) and of hormone replacement therapy (HRT) have been linked to increased blood coagulation, with its increased risk of cardiovascular problems. Their long-term use also has been linked to altered immune and inflammatory factors, suggesting an increased risk of chronic immune disorders with an inflammatory component, including cancer. This report reviews these various risks.