Abstracts & Commentary
Comparing placebo versus the B-vitamin complex intervention, the group receiving the B-vitamin complex demonstrated significant reduction of overall brain atrophy. When looking at just the placebo group, those with homocysteine levels above the median had greater gray matter atrophy than those with homocysteine levels below the median.
After the 8-week myo-inositol treatment, there was a significant reduction in LH/FSH ratio, FSH, prolactin, androstenedione, testosterone, insulin, and BMI compared to baseline; there was also a significant increase in the glucose/insulin ratio.
Compared with men in the lowest quartile of total long-chain omega-3 fatty acids, men in the highest quartile had a 44% increased risk for low-grade prostate cancer, a 71% increased risk for high-grade prostate cancer, and a 43% increased risk for all grades of prostate cancer.
With 1 in 3 Americans having high blood pressure, antihypertensive drugs are among the most frequently prescribed medicines in America. There are 11 different antihypertensive drug classes to choose from, each with its own risks and side effects. For those requiring a medication for control, this study suggests there may be an associated risk of breast cancer in postmenopausal women taking calcium channel blockers for a long duration.
The theory that estrogen metabolite ratios are predictive of cancer risk is failing in these studies to be predictive. This current paper is one more in a series that call this hypothesis into question. It may be time for our profession to reassess the theory and rethink the clinical practices we have adopted based on these assumptions.
Nut consumption was associated with a significantly reduced risk of all-cause mortality. Compared to non-consumers, subjects consuming nuts >3 servings/week had a 39% lower mortality risk. A similar protective effect against cardiovascular and cancer mortality was observed.