Aune D, Chan DSM, Vieira AR, et al. Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systemic review and meta-analysis of cohort studies. Ann Oncol. 2012;23(10):2536-2546.
Study Parameters Assessed
Data collected for 14 years from The Singapore Chinese Health Study using a 648,387 person-years cohort found that individuals who consumed 2 or more soft drinks per week were twice as likely to develop pancreatic cancer.16 Similarly, a paper published in the American Journal of Clinical Nutrition, using a cohort of 77,797 people followed for 7 years revealed a 93% increase in the occurrence of pancreatic cancer in those who drank 2 or more soft drinks per day.17
Despite the fact that naturally occurring fructose (in fruits and vegetables) is chemically identical to high fructose corn syrup and agave (in sweets and soft drinks), there is a marked difference in the delivery systems.
- Benson A., Myerson R, Sasson A. Pancreatic, Neuroendocrine GI, and Adrenal Cancers Cancer Management: 14th Edition ebook.
- National Cancer Institute. http://www.cancer.gov/cancertopics/types/pancreatic. Accessed June 5, 2012.
- Iodice S, Gandini S, Maisonneuve P, et al. Animal fat consumption and pancreatic cancer incidence: evidence of interaction with cigarette smoking. Ann Epidemiol. 2005;15:500-508.
- Huxley R, Ansary-Moghaddam A, Berrington de Gonzalez A, Barzi F, Woodward M. Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies. Br J Cancer. 2005;92:2076-2083.
- Aune D, Greenwood DC, Chan DS, et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta- analysis of prospective studies. Ann Oncol. 2012;23:843-852.
- Aune D, Chan DS, Vieira AR, et al. Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies. Ann Oncol. 2012;23(10):2536-2546.
- United States Department of Agriculture. http://www.usda.gov/factbook/chapter2.pdf. Accessed September 3, 2012.
- Vos MB, Kimmons JE, Gillespie C, et al. Dietary fructose consumption among US children and adults: the third national health and nutrition examination survey. Medscape J Med. 2008;10(7):160.
- Meyer KA, Kushi LH, Jacobs DR, et al. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 2000;71:921-930.
- Montonen J, Jarvinen R, Heliovaara M, et al. Food consumption and the incidence of type II diabetes mellitus. Eur J Clin Nutr. 2005;59:441-448.
- Stanhope KL, Schwarz JM, Keim NL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest. 2009;119:1322-1334.
- Perez-Pozo SE, Schold J, Nakagawa T, et al. Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes (Lond). 2010;34:454-461.
- Liu H, Huang D, McArthur DL, et al. Fructose induces transketolase flux to promote pancreatic cancer growth. Cancer Res. 2010;70:6368-6376.
- Port AM, Ruth AR, Istfan NW. Fructose consumption and cancer: is there a connection? Curr Opin Endocrinol Diabetes Obes. 2012;19(5):367-374.
- Mueller NT, Odegaared A, Anderson K, et al. Soft drink and juice consumption and risk of pancreatic cancer: the Singapore Chinese health study. Cancer Epidemiol Biomarkers Prev. 2010;19(2):447-455.
- Larsson SC, Bergkvist L, Wolk A. Consumption of sugar and sugar sweetened foods and the risk of pancreatic cancer in a prospective study. Am J Clin Nutr. 2006;84(5):1171-1176.
- Jansen RJ, Robinson DP, Stolzenberg-Solomon RZ, et al. Fruit and vegetable consumption is inversely associated with having pancreatic cancer. Cancer Causes Control. 2011;22(12):1613-1625.