December 2016 Vol. 8 Issue 12

Abstracts & Commentary

Acetaminophen and Risk of Behavioral Problems in Children

by Michael T. Murray, ND  Associations between prenatal use of acetaminophen and behavioral problems in children adds to concerns about the safety of what is widely considered to be a benign over-the-counter remedy for pain and fever.

Does Magnesium Really Help Hot Flashes?

by Jacob Schor, ND, FABNO  Previous studies suggested magnesium could be an effective treatment for hot flashes. A new study finds the mineral is no better than placebo—but still effective.

Saffron Powerfully Modulates Anxiety and Depression

by Mark Davis, ND  A randomized controlled trial finds saffron extract reduces symptoms of both anxiety and depression, with benefits similar to a leading antidepressant medication.

Colorectal Cancer Risk Reduction Using Metformin

by Davis W. Lamson, ND  Last month we learned of metformin’s anticancer benefits in breast cancer. This month we review the evidence for its potential to prevent colorectal cancer. And again we ask, “What place does metformin have in natural medicine?”

Peer-Reviewed Articles

A Hydrolyzed Casein Standardized to Lactotripeptides for Support of Vascular Health

by Ginny Bank, MS  Lactotripeptides (LTPs) found in fermented milk have been shown to have potential antihypertensive properties by acting as angiotensin-converting enzyme (ACE) inhibitors. A standardized LTP product, with levels of LTP higher than what is available from dairy products, has also been shown in both in vitro and animal models to induce nitric oxide (NO) production and attenuate atherosclerosis. Clinical research has confirmed that LTP can promote vasodilation, improve endothelial function, and mitigate arterial stiffness in prehypertensive and hypertensive subjects. In this review of published research on the standardized LTP product, we discuss its established mechanisms of action and the randomized placebo-controlled clinical trials that document its potential beneficial effects on cardiovascular health.