August 2013 Vol. 5 Issue 8

Peer-Reviewed Articles

Tamoxifen and CYP2D6

by Richard Malik, ND  The standard of care is clear: Drugs that interfere with the formation of active tamoxifen metabolites are important to consider and relevant to patient care, but genetic polymorphisms that do the same are not.

Activated Charcoal: Bottom Line Monograph

by Natural Standard Activated charcoal is a carbon-rich material that has been processed to have an increased surface area. It is widely used for treating drug overdoses and poisonings, but it also has been studied for many stomach disorders, including diarrhea, gas, and indigestion. In this monograph, Natural Standard offers a thorough review of all the research on activated charcoal's health effects.

Abstracts & Commentary

Do Fatty Acids Really Increase Risk of Prostate Cancer?

by Douglas MacKay, ND  Compared with men in the lowest quartile of total long-chain omega-3 fatty acids, men in the highest quartile had a 44% increased risk for low-grade prostate cancer, a 71% increased risk for high-grade prostate cancer, and a 43% increased risk for all grades of prostate cancer.

Resveratrol Decreases Inflammation

by Heather Hausenblas, PhD  At the end of the 6-week intervention, the men in the resveratrol group had a significant decrease in tumor necrosis factor-α and interleukin 6 compared to the placebo control group.

Vegetable Intake and Prostate Cancer Mortality

by Jacob Schor, ND, FABNO  Replacing 10% of energy intake from carbohydrates with vegetable fat was associated with a 29% lower risk of lethal prostate cancer and 26% lower all-cause mortality.

Myo-Inositol in Polycystic Ovarian Syndrome

by Setareh Tais, ND  After the 8-week myo-inositol treatment, there was a significant reduction in LH/FSH ratio, FSH, prolactin, androstenedione, testosterone, insulin, and BMI compared to baseline; there was also a significant increase in the glucose/insulin ratio.

Will B Vitamins Prevent Alzheimer's Disease?

by Benjamin Lynch, ND  Comparing placebo versus the B-vitamin complex intervention, the group receiving the B-vitamin complex demonstrated significant reduction of overall brain atrophy. When looking at just the placebo group, those with homocysteine levels above the median had greater gray matter atrophy than those with homocysteine levels below the median.