Peer-Reviewed Articles

5-HTP is the precursor of the neurotransmitter serotonin. Commercially available 5-HTP is obtained from the seeds of the plant Griffonia simplicifolia. 5-HTP has been suggested as a treatment for many conditions. This monograph summarizes the research on the 5-HTP, including information on its most and least effective uses.
Vitamin B12 is an essential water-soluble vitamin that is commonly found in a variety of foods, such as fish, shellfish, meat, eggs, and dairy products. B12 plays an important role in supplying essential methyl groups for protein and DNA synthesis.
The protective effects of omega 3 fatty acids found in fish and fish oil supplementation on cardiovascular risks and diseases has been a topic of robust research for the past 30 plus years. This paper cites select research to review trials in coronary heart disease, atherosclerosis, arrhythmias, hypertension, heart failure, and dyslipidemia to encourage among clinicians and consumers a more specific utilization of dietary advice and fish oil supplementation.
Research now suggests that regular aspirin use protects against breast cancer, possibly lowering risk of development and, more significantly, preventing disease recurrence. Study data from Holmes et al have shown a clinically significant protective effect against breast cancer recurrence to the degree that recommendations to take aspirin may become more common despite some inconsistencies in past research. Potential risks vs. possible benefits should now be considered in women at high risk for primary breast cancer, and especially in those women at risk of recurrence.
Vitamin E has been proposed for the prevention or treatment of numerous health conditions, often based on its antioxidant properties. Ongoing research is investigating its use in numerous diseases, particularly in cancer and heart disease. Concerns have been raised about the safety of vitamin E supplementation, particularly in high doses. Evidence suggests that regular use of high-dose vitamin E supplements may increase the risk of death from all causes by a small amount, although human research is conflicting.
Anxiety is a common complaint and may range from every day stress to clinically relevant symptoms requiring medical intervention. Patients with generalized anxiety disorder (GAD) can experience excessive anxiety and worry associated with the stresses of everyday life.
With the growing popularity of red yeast rice (RYR) as a lipid-lowering agent, it is important to ensure that this dietary supplement is safe and effective. The objective of this review was to provide current evidence-based guidance on the use of RYR. PubMed was searched for RYR studies published 2009–2011. The review confirmed that RYR is safe and efficacious for dyslipidemia and has other potential cardioprotective applications.
Editor In Chief
The incidence of colorectal cancer is highest in Western populations. It is thought that the reason for this is largely modifiable lifestyle factors. Primary care practitioners are uniquely positioned to influence the habits of their patients. Screening and early diagnosis have profound effects on the prognosis of individuals with colorectal cancer, and recognizing those at high risk may save lives through early detection. In addition, many evidence-based nutritional interventions exist that may reduce the risk of developing colorectal cancer in those at high risk.