Peer Reviewed Articles

A Review of the Use of N-Acetyl-Cysteine (NAC) in Clinical Practice

by Timothy Schwaiger, ND
With its anti-inflammatory, antioxidant, antimicrobial, and anticarcinogenic properties, NAC can play a role in the treatment of respiratory, hepatological, neurological, and psychiatric conditions.

Medication-Induced Osteoporosis

by John Neustadt, ND
With 44% of men and 57% of women in the United States aged 65 years or more taking at least 5 medications, it is important for clinicians to know that several commonly prescribed medications cause osteoporosis and increase fracture risk. This review will help clinicians understand which common medications have adverse skeletal effects, their mechanisms of action, and how to mitigate the damage or change the medication.

Topical CBD for Pain

by Jamie Corroon, ND, MPH
Given the lower risk of adverse effects and the high reported tolerability, topical cannabidiol treatments for chronic pain may represent an underutilized therapy.

Making Sense of Osteoporosis Testing

by John Neustadt, ND
A review of the diagnostic and screening technologies and common laboratory tests for predicting, treating, and monitoring osteoporosis and fractures.

Floatation Therapy for Specific Health Concerns

by Laura Witte, PhD, PA-C
Floatation therapy appears to be a safe, natural option for conditions such as pain, depression, anxiety, stress, and sleep disorders that could potentially reduce medication requirements.

Stress, Immunity, and Hair Health

Chronic stress can lead to the collapse of immune privilege and inflammatory cascades in hair follicles that result in hair loss. Natural interventions, such as specific nutritional supplements, diets, electroacupuncture, and more, can help address the problem at the root to restore healthy hair.

Reinforcing the Immune System with Natural Health Supplements in the Era of Covid-19 and Upper Respiratory Tract Infections

by Will Cheng, MD
Covid-19 has become a global pandemic affecting tens of millions of people worldwide and resulting in the death of well over 1 million people. While vaccines against the SARS-CoV-2 virus are emerging, there remains an unmet need for safe, cost-effective, and readily available treatments. In the absence of direct evidence relating to Covid-19, the goal of this article is to review the key preclinical and clinical data that support immunomodulatory properties of natural health supplements.

Antiangiogenic Phytochemicals Best Poised for Clinical Trial Testing

by Athanasios Psihogios, ND
Green tea, curcumin, resveratrol, and ginsenosides have some of the most robust evidence for inhibiting malignant angiogenesis in a clinically meaningful way.

Recommending Intermittent Fasting

by Ronald Hoffman, MD
For health and longevity, the timing of when we eat and when we fast profoundly affects our physiology.

Highlighting Alpha Lipoic Acid in Diabetes

by Tina Kaczor, ND, FABNO
Alpha lipoic acid (ALA), given orally or intravenously, affects many conditions in which oxidation and inflammation are involved. One of the conditions for which exogenous ALA has been most studied is diabetes. Understanding ALA’s structure and use as an exogenous agent that is more akin to a drug than a nutrient, with particular attention to diabetes and diabetic peripheral neuropathy, is the topic of this review.

An Updated Review on Hormone Replacement Therapy for Menopausal Women

by Timothy Schwaiger, ND
Menopause can be a challenge for women who suffer from unwanted symptoms including insomnia associated with night sweats and hot flashes, vaginal dryness, and chronic urinary problems. In addition, for those contemplating hormone replacement therapy (HRT) while evaluating its use and the potential for aggravating side effects and medical risks, the information available to the public can be confusing.

Beneficial Effects of a Sulfur-Containing Supplement on Hair and Nail Condition

by Neelam Muizzuddin, PhD
Significant changes were observed in as little as 2 weeks of dietary supplementation.

Diet and Risk of Prostate Cancer Recurrence

by Jacob Schor, ND, FABNO
This peer-reviewed paper presents a comprehensive review of the latest evidence to support specific dietary recommendations for men with prostate cancer. Data suggests there is no one-size-fits-all solution; recommendations for prevention may differ from those for reducing risk of progression or recurrence, and there may even be inter-individual variation.

Demographic and Outcome Trends in Naturopathic Teaching Clinics

by Kimberly Sanders, ND
A pilot study explores individualized naturopathic care and health-related quality of life in 2 demographically distinct clinic populations.

Arum palaestinum as a Food-Medicine

by Benton Bramwell, ND
Commonly known as Solomon’s lily, Arum palaestinum is an edible, flowering plant that has been used in Traditional Arabic Palestinian herbal medicine for millennia, both as food and as treatment for a wide variety of ailments. A literature review of both in vitro and in vivo studies sheds light on its potential as an anticancer treatment for modern times.

Oncology Acupuncture Program Assessment at Oregon Health and Science University

by Yiyi Chen, PhD
A retrospective analysis aims to create a profile of cancer patients who opt to receive acupuncture for treatment-related symptoms, to inform symptom assessment and shed light on acupuncture efficacy in this subpopulation.

Thiamine Deficiency and Diabetic Polyneuropathy

by Richard H. Mann, DPM
An exploration of the complex metabolic pathways that connect thiamine deficiency to complications of diabetes.

Let’s Talk About Sex: Sexuality During and After Cancer Treatment

by Judith Boice, ND, LAc, FABNO
Cancer and cancer treatments present special challenges that can affect sexuality and sexual desire. A review article thoughtfully addresses this overlooked aspect of patient care and provides practical suggestions for enhancing intimacy.

The Gut-Skin Axis and Mechanisms for Communication

by Raja Sivamani, MD
The association of gut health to general health has been the focus of many medical approaches, including traditional Chinese medicine, Ayurvedic medicine, and naturopathic medicine. The discovery of the gut microbiome has led to new areas of research that focus on the possible biochemical mechanisms that can relate gut health to local disease as well as the health of distant organs. The relationship of the gut to the skin, referred to as the gut-skin axis, is one emerging area of research.

Testosterone Deficiency Diagnosis and Replacement Therapy

by Timothy Schwaiger, ND
The use of testosterone replacement therapy (TRT) for men has risen dramatically in recent years. This comprehensive review article covers many aspects of TRT, including testosterone metabolism, indications for TRT, diagnostic testing with a decision-to-treat algorithm, contraindications, and risks vs benefits of treatment.