Peer Reviewed Articles

N-Acetylglucosamine for Treatment of Inflammatory Bowel Disease

by Andy Z. X. Zhu, PhD
04-01-2015 
Inflammatory bowel disease (IBD) is associated with a widespread breakdown of glycosaminoglycans, which are normally attached to mucin and help to form a protective barrier separating bacteria from the intestinal epithelium. N-acetylglucosamine (NAG) is a naturally occurring amino sugar precursor for epithelial glycosaminoglycan synthesis. This pragmatic open-label clinical trial assessed the efficacy and safety of NAG and demonstrated that NAG could be an efficacious adjunctive treatment for IBD.

Atopic Dermatitis in Pediatric Patients

by Kristina Roberts, ND
03-04-2015 
Atopic dermatitis (AD) continues to increase in prevalence. In 30% to 40% of patients, this condition persists into adulthood. These statistics reflect poorly on the standard-of-care therapies that fail to address the root cause of AD and therefore cannot cure it. This overview describes treatment considerations that address the underlying cause, which is imperative to treatment success and patient satisfaction.

Plant Tannins

by Catherine Clinton, ND
03-02-2015 

The Prevención con Dieta Mediterránea Cohort, 2 Years Later

by Jacob Schor, ND, FABNO
02-25-2015 
The Prevención con Dieta Mediterránea (PREDIMED) study was the largest prospective randomized controlled experiment examining the effects of a Mediterranean style diet ever conducted. It may be the most valuable clinical trial on diet ever performed. It is important for us to understand the knowledge gained from both the original report and the subsequent publications derived from study cohorts.

Metabolic Considerations in Autism Spectrum Disorder

by Elizabeth Mumper, MD
02-04-2015 
Autism spectrum disorder (ASD), a disorder characterized by social, communication, and behavioral impairments, has increased dramatically in recent years. The conventional medical paradigm defines ASD as a neurological disorder. Conventional treatments rely on behavioral therapies and psychotropic medications but have limited success and tolerability. A new paradigm is emerging that views ASD as a multisystem disorder accompanied by metabolic and mitochondrial impairments. A clinical approach to assess and treat metabolic dysfunction in ASD is reviewed here.

Inositol and Polycystic Ovarian Syndrome

by Megan Chmelik
12-03-2014 
This review highlights inositol, specifically in the forms of myo-inositol and d-chiro inositol, in order to provide up-to-date information that can be applied to a clinical setting for the naturopathic treatment of polycystic ovarian syndrome.

Natural Interventions for Posttreatment Cancer-related Fatigue

by Lise Alschuler, ND, FABNO
11-05-2014 
Studies have consistently demonstrated that cancer-related fatigue is one of the most common debilitating side effects of radiation and chemotherapy, as well as the malignant process itself. Quality of life can be significantly and negatively impacted in cancer survivors who experience fatigue and other common symptoms, including sleep disturbance, pain, depression, and anxiety. Presently, pharmacological options are limited and are often associated with further side effects. An integrative approach that, in addition to optimizing lifestyle, employs specific natural agents can safely and effectively enhance energy levels after conventional cancer treatments.

Natural Antimicrobial Compounds in Small Intestinal Bacterial Overgrowth Syndrome

by John Deaton, PhD
10-01-2014 
The purpose of this trial was to determine if a combination of naturally occurring antimicrobials can allow reduction and suppression of the invading microorganisms under physiological conditions, so when the combination is given to a patient before eating, the nutrients will be broken down and used by the body, the body will have time to heal, and the probiotics will establish control over the pathogenic bacteria.

Galectin-3 as an Oncological Biomarker

by Isaac Eliaz, MD, MS, LAc
09-03-2014 
This review summarizes the pathophysiological connection of galectin-3 and cancer presently in the literature, as well as the potential clinical value of galectin-3 as a prognostic oncology biomarker. Based on the preliminary data, the galectin-3 assay could become a contributing tool to help clinicians monitor treatment response and tumor progression, but further clinical studies evaluating galectin-3 levels and cancer progression are warranted.

Bioidentical Hormone Replacement Therapy in Postmenopausal Osteoporosis

by Sarah Bedell Cook, ND
08-28-2014 
Osteoporosis is estimated to affect more than 10 million Americans, with postmenopausal women at particular risk. Osteoporotic fractures can lead to postural changes, emotional distress, and chronic pain. Currently all medications approved by the US Food and Drug Administration for the treatment of osteoporosis carry slight to modest risks depending on the individual, the duration, the dosage, and the drug being used. Estrogen replacement therapy is not currently indicated for the treatment of osteoporosis, but it is approved for osteoporosis prevention. Interest in bioidentical hormone replacement as an alternative to conventional hormone replacement has increased in the last 12 years, although not always for logical or scientific reasons. The purpose of this review is to bring clinicians up to date on current information on the efficacy and safety of bioidentical hormones for the prevention of postmenopausal osteoporosis.

Nonalcoholic Fatty Liver Disease

by Todd A. Born, ND
08-06-2014 
Nonalcoholic fatty liver disease (NAFLD) is subdivided into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). In the United States, prevalence of NAFLD is 10% to 46% of the population. Worldwide prevalence is 6% to 35% (median 20%). There is a need to increase understanding of liver disease and its many causes, which will help to improve patient outcomes and reduce the stigma many patients experience. This article discusses epidemiology, etiologies, suspected pathogenesis, and risk factors, along with conventional and naturopathic therapeutic treatment options.

Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study

by Kentaro Kitadate, DVM
07-02-2014 
Poor blood circulation often manifests as small but chronic temperature differences in the peripheral extremities, and the surface of the skin may be an indication of abnormal blood flow and more serious vascular or circulation disorders. This study investigates the effect of Oligonol, a highly bioavailable source of low–molecular weight polyphenols extracted from lychee fruit, on peripheral blood circulation using skin thermography. The results suggest that Oligonol might act as a vasodilator and be an effective treatment for a variety of vasoconstriction symptoms such as cold hands and feet, shoulder discomfort, and diabetes-related vascular problems.

Iodine and Cancer

by Tina Kaczor, ND, FABNO
06-04-2014 
Iodine is an essential element in human physiology. Its role in thyroid function is well known and heavily weighted in the literature. Its putative role as an anticarcinogenic agent is just beginning to be widely appreciated. The molecular effects of iodine as well as ongoing epidemiological evidence points to its probable role in prevention of cancers through its antioxidant, antiinflammatory, prodifferentiating, and proapoptotic effects. This is particularly evident with stomach and breast cancers but may be relevant for many other cancers that have yet to be substantially studied.

Treatment of Dermal Infections With Topical Coconut Oil

by Lindsey K. Elmore, PharmD, BCPS
05-07-2014 
Coconut oil, and many other portions of the plant Cocos nucifera L, have been hypothesized to have antimicrobial and antifungal activity. Medium-chain fatty acid constituents of coconut oil including lauric acid, capric acid, and others provide antimicrobial effect by disrupting bacterial, fungal, and viral cell membranes, leading to cell death. This review summarizes in vivo and in vitro studies of topical anti-infective properties of coconut oil and the medium-chain fatty acids contained within, and describes the proposed use of coconut products for dermal infections.

Treatment Considerations for Generalized Anxiety Disorder

by Lise Alschuler, ND, FABNO
04-02-2014 
A multi-pronged approach to generalized anxiety disorder (GAD) is considered the most effective and safest way to treat anxiety due to the wide range of causal factors and dysregulation of various neurotransmitters that are often involved. With a focus on correcting neurotransmitter imbalances in the limbic system, as well as hypothalamic-pituitary-adrenal (HPA) axis dysfunction, clinicians can choose from several scientifically supported nutrients and herbs the ones that are most appropriate for each patient to modulate these pathways and change the course of this disorder.

Effects of Green Coffee Bean Extract on Weight Loss

by Heather Hausenblas, PhD
03-01-2014 
In the past decade, increased research and media attention has been given to the weight loss effects of green coffee bean extract (GCBE). The purpose of our study was to perform a review and meta-analysis of available randomized clinical trials examining the effects of GCBE supplementation on weight loss in both normal weight and overweight/obese individuals.

Intravenous Vitamin C in Cancer

by Michael Traub, ND, DHANP, FABNO
02-13-2014 
New information has become available about the clinical use of intravenous vitamin C in recent years, particularly in its application in cancer. However, great variability in practice persists, reflecting a lack of knowledge of how this treatment should be most safely and effectively employed. This article reviews the forms of nutrients that best balance changes in blood chemistry inherent in this therapy and the appropriate use of B vitamins and glutathione.

Identifying and Treating Metabolic Syndrome in Breast Cancer

by Jen Green, ND, FABNO
02-01-2014 
Metabolic syndrome is a common condition that can increase complications in breast cancer treatment and increase risk of recurrence. While metformin is a promising therapeutic agent, intensive lifestyle interventions and natural therapies can be safely and effectively implemented in people with metabolic syndrome before they become diabetic. Natural medicine interventions such as exercise, dietary counseling, herbal medicine, and dietary supplementation can help optimize outcomes during and after cancer treatment. Strategies discussed in this article include various diets, management of cortisol levels, sleep, avoidance of obesogenic compounds, and use of the nutrients chromium, zinc, vanadium, magnesium, myo-inositol, alpha lipoic acid, fish oil, vitamin D, CoQ10, L-carnitine, herbal bitters, cinnamon, berberine, and green tea.

Nutrient Profile: Zinc-Carnosine

by Tori Hudson, ND
11-01-2013 

Effects of Resveratrol and Collagen Supplementation on Facial Aging

by Heather Hausenblas, PhD
10-01-2013 
The participants reported significant improvements in skin satisfaction and body satisfaction after taking Collagen Booster for 6 months. More specifically, participants reported significantly higher body and skin satisfaction scores at the 3- and 6-month visits compared to their baseline visits.