Peer Reviewed Articles

Bioidentical Hormone Replacement Therapy in Postmenopausal Osteoporosis

by Sarah Bedell Cook, ND
08-28-2014 
Osteoporosis is estimated to affect more than 10 million Americans, with postmenopausal women at particular risk. Osteoporotic fractures can lead to postural changes, emotional distress, and chronic pain. Currently all medications approved by the US Food and Drug Administration for the treatment of osteoporosis carry slight to modest risks depending on the individual, the duration, the dosage, and the drug being used. Estrogen replacement therapy is not currently indicated for the treatment of osteoporosis, but it is approved for osteoporosis prevention. Interest in bioidentical hormone replacement as an alternative to conventional hormone replacement has increased in the last 12 years, although not always for logical or scientific reasons. The purpose of this review is to bring clinicians up to date on current information on the efficacy and safety of bioidentical hormones for the prevention of postmenopausal osteoporosis.

Nonalcoholic Fatty Liver Disease

by Todd A. Born, ND
08-06-2014 
Nonalcoholic fatty liver disease (NAFLD) is subdivided into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). In the United States, prevalence of NAFLD is 10% to 46% of the population. Worldwide prevalence is 6% to 35% (median 20%). There is a need to increase understanding of liver disease and its many causes, which will help to improve patient outcomes and reduce the stigma many patients experience. This article discusses epidemiology, etiologies, suspected pathogenesis, and risk factors, along with conventional and naturopathic therapeutic treatment options.

Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study

by Kentaro Kitadate, DVM
07-02-2014 
Poor blood circulation often manifests as small but chronic temperature differences in the peripheral extremities, and the surface of the skin may be an indication of abnormal blood flow and more serious vascular or circulation disorders. This study investigates the effect of Oligonol, a highly bioavailable source of low–molecular weight polyphenols extracted from lychee fruit, on peripheral blood circulation using skin thermography. The results suggest that Oligonol might act as a vasodilator and be an effective treatment for a variety of vasoconstriction symptoms such as cold hands and feet, shoulder discomfort, and diabetes-related vascular problems.

Iodine and Cancer

by Tina Kaczor, ND, FABNO
06-04-2014 
Iodine is an essential element in human physiology. Its role in thyroid function is well known and heavily weighted in the literature. Its putative role as an anticarcinogenic agent is just beginning to be widely appreciated. The molecular effects of iodine as well as ongoing epidemiological evidence points to its probable role in prevention of cancers through its antioxidant, antiinflammatory, prodifferentiating, and proapoptotic effects. This is particularly evident with stomach and breast cancers but may be relevant for many other cancers that have yet to be substantially studied.

Treatment of Dermal Infections With Topical Coconut Oil

by Lindsey K. Elmore, PharmD, BCPS
05-07-2014 
Coconut oil, and many other portions of the plant Cocos nucifera L, have been hypothesized to have antimicrobial and antifungal activity. Medium-chain fatty acid constituents of coconut oil including lauric acid, capric acid, and others provide antimicrobial effect by disrupting bacterial, fungal, and viral cell membranes, leading to cell death. This review summarizes in vivo and in vitro studies of topical anti-infective properties of coconut oil and the medium-chain fatty acids contained within, and describes the proposed use of coconut products for dermal infections.

Treatment Considerations for Generalized Anxiety Disorder

by Lise Alschuler, ND, FABNO
04-02-2014 
A multi-pronged approach to generalized anxiety disorder (GAD) is considered the most effective and safest way to treat anxiety due to the wide range of causal factors and dysregulation of various neurotransmitters that are often involved. With a focus on correcting neurotransmitter imbalances in the limbic system, as well as hypothalamic-pituitary-adrenal (HPA) axis dysfunction, clinicians can choose from several scientifically supported nutrients and herbs the ones that are most appropriate for each patient to modulate these pathways and change the course of this disorder.

Effects of Green Coffee Bean Extract on Weight Loss

by Heather Hausenblas, PhD
03-01-2014 
In the past decade, increased research and media attention has been given to the weight loss effects of green coffee bean extract (GCBE). The purpose of our study was to perform a review and meta-analysis of available randomized clinical trials examining the effects of GCBE supplementation on weight loss in both normal weight and overweight/obese individuals.

Intravenous Vitamin C in Cancer

by Michael Traub, ND, DHANP, FABNO
02-13-2014 
New information has become available about the clinical use of intravenous vitamin C in recent years, particularly in its application in cancer. However, great variability in practice persists, reflecting a lack of knowledge of how this treatment should be most safely and effectively employed. This article reviews the forms of nutrients that best balance changes in blood chemistry inherent in this therapy and the appropriate use of B vitamins and glutathione.

Identifying and Treating Metabolic Syndrome in Breast Cancer

by Jen Green, ND, FABNO
02-01-2014 
Metabolic syndrome is a common condition that can increase complications in breast cancer treatment and increase risk of recurrence. While metformin is a promising therapeutic agent, intensive lifestyle interventions and natural therapies can be safely and effectively implemented in people with metabolic syndrome before they become diabetic. Natural medicine interventions such as exercise, dietary counseling, herbal medicine, and dietary supplementation can help optimize outcomes during and after cancer treatment. Strategies discussed in this article include various diets, management of cortisol levels, sleep, avoidance of obesogenic compounds, and use of the nutrients chromium, zinc, vanadium, magnesium, myo-inositol, alpha lipoic acid, fish oil, vitamin D, CoQ10, L-carnitine, herbal bitters, cinnamon, berberine, and green tea.

Nutrient Profile: Zinc-Carnosine

by Tori Hudson, ND
11-01-2013 

Effects of Resveratrol and Collagen Supplementation on Facial Aging

by Heather Hausenblas, PhD
10-01-2013 
The participants reported significant improvements in skin satisfaction and body satisfaction after taking Collagen Booster for 6 months. More specifically, participants reported significantly higher body and skin satisfaction scores at the 3- and 6-month visits compared to their baseline visits.

Preventive Cardiology

by Stephen W. Parcell, ND
09-01-2013 
The current standard of care does not include detection of asymptomatic atherosclerosis. Instead, traditional risk factors are evaluated, the patient is put into a low-, medium-, or high-risk category, and lipid targets are determined by the clinician depending on the category. Thus, coronary artery disease is not detected early. We know that early detection of cancer saves lives. The same is true for atherosclerosis.

Activated Charcoal: Bottom Line Monograph

by Natural Standard
08-01-2013 
Activated charcoal is a carbon-rich material that has been processed to have an increased surface area. It is widely used for treating drug overdoses and poisonings, but it also has been studied for many stomach disorders, including diarrhea, gas, and indigestion. In this monograph, Natural Standard offers a thorough review of all the research on activated charcoal's health effects.

Tamoxifen and CYP2D6

by Richard Malik, ND
08-01-2013 
The standard of care is clear: Drugs that interfere with the formation of active tamoxifen metabolites are important to consider and relevant to patient care, but genetic polymorphisms that do the same are not.

Honokiol Research Review

by Isaac Eliaz, MD, MS, LAc
07-01-2013 
In this literature review we discuss the accumulating body of preclinical research which shows honokiol to have wide-ranging biological and clinically relevant effects, without appreciable toxicity. In vivo studies suggest that honokiol’s greatest value is in its multiple anticancer actions.

Optimal Longevity Hinges on Telomeres

by Lise Alschuler, ND, FABNO
06-01-2013 
Systemically and over a lifespan, abnormal telomere shortening predicts risk for chronic diseases, namely cardiovascular disease and cancer. The opportunity to improve healthy longevity lies in preventing premature telomere shortening.

Frankincense's Efficacy in Treating Osteoarthritis

by Jeremy Appleton, ND
05-01-2013 
Boswellia is an ancient remedy with numerous modern clinical applications. Extracts of the gum resin with 20% to 30% AKBA represent viable alternative treatments of osteoarthritis. Boswellia extract is also a promising treatment for other inflammatory conditions, including asthma, rheumatoid arthritis, and cerebral edema. Further research is needed to adequately assess its efficacy for these applications.

A Pilot Study to Evaluate the Antihypertensive Effect of a Celery Extract in Mild to Moderate Hypertensive Patients

by Doddabele Madhavi, PhD
04-01-2013 
Celery extract has been shown in animal studies to help prevent stroke, improve blood flow, and act to protect the brain and enhance energy production.

Resveratrol: Bottom Line Monograph

by Natural Standard
03-01-2013 
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use.

The Economic Evaluation of Complementary and Alternative Medicine

by Setareh Tais, ND
02-01-2013 
The use of complementary and alternative medicine (CAM) has steadily grown in recent decades, followed by an increase in insurance coverage for various CAM providers (eg, naturopathic physicians, acupuncturists, massage therapist, chiropractors). However, with rising healthcare costs, insurers and policy makers have expressed concerns about the cost-effectiveness of healthcare, both conventional and CAM. Although more prospective outcome studies are needed to evaluate the cost-effectiveness of CAM, there have been published research studies demonstrating that CAM is cost-effective and may present cost-savings due to inexpensive treatments, lower technology interventions, and its emphasis on preventative medicine.