Peer Reviewed Articles

Preventive Cardiology

by Stephen W. Parcell, ND
09-01-2013 
The current standard of care does not include detection of asymptomatic atherosclerosis. Instead, traditional risk factors are evaluated, the patient is put into a low-, medium-, or high-risk category, and lipid targets are determined by the clinician depending on the category. Thus, coronary artery disease is not detected early. We know that early detection of cancer saves lives. The same is true for atherosclerosis.

Tamoxifen and CYP2D6

by Richard Malik, ND
08-01-2013 
The standard of care is clear: Drugs that interfere with the formation of active tamoxifen metabolites are important to consider and relevant to patient care, but genetic polymorphisms that do the same are not.

Activated Charcoal: Bottom Line Monograph

by Natural Standard
08-01-2013 
Activated charcoal is a carbon-rich material that has been processed to have an increased surface area. It is widely used for treating drug overdoses and poisonings, but it also has been studied for many stomach disorders, including diarrhea, gas, and indigestion. In this monograph, Natural Standard offers a thorough review of all the research on activated charcoal's health effects.

Honokiol Research Review

by Isaac Eliaz, MD, MS, LAc
07-01-2013 
In this literature review we discuss the accumulating body of preclinical research which shows honokiol to have wide-ranging biological and clinically relevant effects, without appreciable toxicity. In vivo studies suggest that honokiol’s greatest value is in its multiple anticancer actions.

Optimal Longevity Hinges on Telomeres

by Lise Alschuler, ND, FABNO
06-01-2013 
Systemically and over a lifespan, abnormal telomere shortening predicts risk for chronic diseases, namely cardiovascular disease and cancer. The opportunity to improve healthy longevity lies in preventing premature telomere shortening.

Frankincense's Efficacy in Treating Osteoarthritis

by Jeremy Appleton, ND
05-01-2013 
Boswellia is an ancient remedy with numerous modern clinical applications. Extracts of the gum resin with 20% to 30% AKBA represent viable alternative treatments of osteoarthritis. Boswellia extract is also a promising treatment for other inflammatory conditions, including asthma, rheumatoid arthritis, and cerebral edema. Further research is needed to adequately assess its efficacy for these applications.

A Pilot Study to Evaluate the Antihypertensive Effect of a Celery Extract in Mild to Moderate Hypertensive Patients

by Doddabele Madhavi, PhD
04-01-2013 
Celery extract has been shown in animal studies to help prevent stroke, improve blood flow, and act to protect the brain and enhance energy production.

Resveratrol: Bottom Line Monograph

by Natural Standard
03-01-2013 
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use.

The Economic Evaluation of Complementary and Alternative Medicine

by Setareh Tais, ND
02-01-2013 
The use of complementary and alternative medicine (CAM) has steadily grown in recent decades, followed by an increase in insurance coverage for various CAM providers (eg, naturopathic physicians, acupuncturists, massage therapist, chiropractors). However, with rising healthcare costs, insurers and policy makers have expressed concerns about the cost-effectiveness of healthcare, both conventional and CAM. Although more prospective outcome studies are needed to evaluate the cost-effectiveness of CAM, there have been published research studies demonstrating that CAM is cost-effective and may present cost-savings due to inexpensive treatments, lower technology interventions, and its emphasis on preventative medicine.

Assessing Egg Quantity with Anti-Mullerian Hormone

by Setareh Tais, ND
01-01-2013 
Diminished ovarian reserve, a natural process by which the follicular pool diminishes with time, is often clinically asymptomatic but presents a challenge to those wanting to become pregnant. Although pelvic ultrasonography and day 3 serum hormone testing have long been common methods of assessing ovarian reserve, promising research suggests the utility of anti-mullerian hormone testing to identify patients with diminished ovarian reserve. Conventional wisdom would suggest that in vitro fertilization is the only answer for diminished ovarian reserve, but preliminary research offers hope that egg quality and ovarian reserve can be improved by dehydroepiandrosterone, melatonin, and myo-inositol.

Facts and Myths About Fevers in Children

by Erin Psota, ND
01-01-2013 
As fevers are seen as a beneficial healing process, naturopathic physicians tend to use conventional antipyretics more sparingly than allopathically trained practitioners, depending on patient, parent, and professional comfort.

The Effects of Soy Consumption on Breast Cancer Prognosis

by Tina Kaczor, ND, FABNO
01-01-2013 
Isoflavones from soy have both estrogenic and antiestrogenic action, and in vitro and animal studies have shown possible interference with hormone blockade agents used in breast cancer aftercare. Epidemiological data, however, suggests that soy consumption is not associated with increased risk in any population of women with a history of breast cancer. Further, there appears to be a linear relationship between decreased risk of recurrence and/or mortality and increasing soy consumption.

Primary Risks of Oral Contraceptives and HRT

by Gina Cushman, NMD, PHD
01-01-2013 
Long-term use of oral contraceptives (OCs) and of hormone replacement therapy (HRT) have been linked to increased blood coagulation, with its increased risk of cardiovascular problems. Their long-term use also has been linked to altered immune and inflammatory factors, suggesting an increased risk of chronic immune disorders with an inflammatory component, including cancer. This report reviews these various risks. Also discussed are 2 natural food extracts, one showing anticoagulant effects and the other exhibiting certain anti-inflammatory and immunomodulatory effects.

Top 10 Articles of 2012

by Natural Medicine Journal
01-01-2013 
Happy New Year from all of us at Natural Medicine Journal! Take a look at the articles our readers liked best in 2012.

Clinical Applications for Berberine

by Jacob Schor, ND, FABNO
12-01-2012 
New clinical applications for the alkaloid berberine have come to light in recent years. Applications related to adenosine monophosphate-activated protein kinase (AMPK) activation and berberine's possible therapeutic use in metabolic syndrome, type 2 diabetes, and dyslipdemia are reviewed in this article. Potential applications related to cancer are not discussed here but are reserved for a second review.

Nutrient Profile: Bitter melon (Momordica charantia)

by Tori Hudson, ND
10-01-2012 
Bitter melon has many historical and theoretical uses, ranging from an abortifacient to a hemorrhoid treatment. It also has a long history of use as a hypoglycemic agent. Its hypoglycemic effects have been explored to the greatest extent and have aided in our understanding of its pharmacology and mechanism of action, leading to several studies looking at bitter melon as a hypoglycemic agent in type 1 and type 2 diabetes.

Aloe Vera Gel Research Review

by Oliver Grundmann, BPharm,ms,PHD
09-01-2012 

Generalized Anxiety Disorder and Panic Disorder in Women: A Clinical Perspective

by Tori Hudson, ND
08-01-2012 
Anxiety disorders are among the most common primary care challenges in a women's health practice. A comprehensive approach includes identifying the symptoms, characterizing the disorder, and evaluating whether the patient has a medical condition such as hyperthyroid, substance abuse, supraventricular tachycardia, or asthma that manifests as anxiety.

Breast Thermography: History, Theory, and Use

by Debi Walker, ND
07-01-2012 
More than 50 years has passed since the hypothesis of thermography in breast imaging was proposed. During this time, thermography has gone from a legitimate, promising technology to one relegated to the shadows outside conventional medicine. While thermography is not well evidenced for use as a screening tool, its use as an adjunctive imaging procedure alongside mammography should be considered, particularly for those with dense breast tissue. However, validation of protocols, equipment, and analytical techniques is needed in the context of large, randomized trials before its use can be considered truly evidence-based.

Assessing Egg Quantity with Anti-Mullerian Hormone

by Setareh Tais, ND
06-01-2012 
Diminished ovarian reserve, a natural process by which the follicular pool diminishes with time, is often clinically asymptomatic but presents a challenge to those wanting to become pregnant. Although pelvic ultrasonography and day 3 serum hormone testing have long been common methods of assessing ovarian reserve, there is promising research to suggest the utility of anti-Mullerian hormone testing to identify patients with diminished ovarian reserve.