Peer Reviewed Articles

The Effects of Soy Consumption on Breast Cancer Prognosis

by Tina Kaczor, ND, FABNO
01-01-2013 
Isoflavones from soy have both estrogenic and antiestrogenic action, and in vitro and animal studies have shown possible interference with hormone blockade agents used in breast cancer aftercare. Epidemiological data, however, suggests that soy consumption is not associated with increased risk in any population of women with a history of breast cancer. Further, there appears to be a linear relationship between decreased risk of recurrence and/or mortality and increasing soy consumption.

Primary Risks of Oral Contraceptives and HRT

by Gina Cushman, NMD, PHD
01-01-2013 
Long-term use of oral contraceptives (OCs) and of hormone replacement therapy (HRT) have been linked to increased blood coagulation, with its increased risk of cardiovascular problems. Their long-term use also has been linked to altered immune and inflammatory factors, suggesting an increased risk of chronic immune disorders with an inflammatory component, including cancer. This report reviews these various risks. Also discussed are 2 natural food extracts, one showing anticoagulant effects and the other exhibiting certain anti-inflammatory and immunomodulatory effects.

Top 10 Articles of 2012

by Natural Medicine Journal
01-01-2013 
Happy New Year from all of us at Natural Medicine Journal! Take a look at the articles our readers liked best in 2012.

Assessing Egg Quantity with Anti-Mullerian Hormone

by Setareh Tais, ND
01-01-2013 
Diminished ovarian reserve, a natural process by which the follicular pool diminishes with time, is often clinically asymptomatic but presents a challenge to those wanting to become pregnant. Although pelvic ultrasonography and day 3 serum hormone testing have long been common methods of assessing ovarian reserve, promising research suggests the utility of anti-mullerian hormone testing to identify patients with diminished ovarian reserve. Conventional wisdom would suggest that in vitro fertilization is the only answer for diminished ovarian reserve, but preliminary research offers hope that egg quality and ovarian reserve can be improved by dehydroepiandrosterone, melatonin, and myo-inositol.

Facts and Myths About Fevers in Children

by Erin Psota, ND
01-01-2013 
As fevers are seen as a beneficial healing process, naturopathic physicians tend to use conventional antipyretics more sparingly than allopathically trained practitioners, depending on patient, parent, and professional comfort.

Clinical Applications for Berberine

by Jacob Schor, ND, FABNO
12-01-2012 
New clinical applications for the alkaloid berberine have come to light in recent years. Applications related to adenosine monophosphate-activated protein kinase (AMPK) activation and berberine's possible therapeutic use in metabolic syndrome, type 2 diabetes, and dyslipdemia are reviewed in this article. Potential applications related to cancer are not discussed here but are reserved for a second review.

Nutrient Profile: Bitter melon (Momordica charantia)

by Tori Hudson, ND
10-01-2012 
Bitter melon has many historical and theoretical uses, ranging from an abortifacient to a hemorrhoid treatment. It also has a long history of use as a hypoglycemic agent. Its hypoglycemic effects have been explored to the greatest extent and have aided in our understanding of its pharmacology and mechanism of action, leading to several studies looking at bitter melon as a hypoglycemic agent in type 1 and type 2 diabetes.

Aloe Vera Gel Research Review

by Oliver Grundmann, BPharm,ms,PHD
09-01-2012 

Generalized Anxiety Disorder and Panic Disorder in Women: A Clinical Perspective

by Tori Hudson, ND
08-01-2012 
Anxiety disorders are among the most common primary care challenges in a women's health practice. A comprehensive approach includes identifying the symptoms, characterizing the disorder, and evaluating whether the patient has a medical condition such as hyperthyroid, substance abuse, supraventricular tachycardia, or asthma that manifests as anxiety.

Breast Thermography: History, Theory, and Use

by Debi Walker, ND
07-01-2012 
More than 50 years has passed since the hypothesis of thermography in breast imaging was proposed. During this time, thermography has gone from a legitimate, promising technology to one relegated to the shadows outside conventional medicine. While thermography is not well evidenced for use as a screening tool, its use as an adjunctive imaging procedure alongside mammography should be considered, particularly for those with dense breast tissue. However, validation of protocols, equipment, and analytical techniques is needed in the context of large, randomized trials before its use can be considered truly evidence-based.

Assessing Egg Quantity with Anti-Mullerian Hormone

by Setareh Tais, ND
06-01-2012 
Diminished ovarian reserve, a natural process by which the follicular pool diminishes with time, is often clinically asymptomatic but presents a challenge to those wanting to become pregnant. Although pelvic ultrasonography and day 3 serum hormone testing have long been common methods of assessing ovarian reserve, there is promising research to suggest the utility of anti-Mullerian hormone testing to identify patients with diminished ovarian reserve.

Primary Risks of Oral Contraceptives and HRT

by Gina Cushman, NMD, PHD
05-01-2012 
Long-term use of oral contraceptives (OCs) and of hormone replacement therapy (HRT) have been linked to increased blood coagulation, with its increased risk of cardiovascular problems. Their long-term use also has been linked to altered immune and inflammatory factors, suggesting an increased risk of chronic immune disorders with an inflammatory component, including cancer. This report reviews these various risks.

Colorectal Cancer in Primary Care

by Tina Kaczor, ND, FABNO
04-01-2012 
The incidence of colorectal cancer is highest in Western populations. It is thought that the reason for this is largely modifiable lifestyle factors. Primary care practitioners are uniquely positioned to influence the habits of their patients. Screening and early diagnosis have profound effects on the prognosis of individuals with colorectal cancer, and recognizing those at high risk may save lives through early detection. In addition, many evidence-based nutritional interventions exist that may reduce the risk of developing colorectal cancer in those at high risk.

Red Yeast Rice for Cardioprotection

by Michael Traub, ND, DHANP, FABNO
03-01-2012 
With the growing popularity of red yeast rice (RYR) as a lipid-lowering agent, it is important to ensure that this dietary supplement is safe and effective. The objective of this review was to provide current evidence-based guidance on the use of RYR. PubMed was searched for RYR studies published 2009–2011. The review confirmed that RYR is safe and efficacious for dyslipidemia and has other potential cardioprotective applications.

Siberian Ginseng: A Review of the Literature

by Natural Standard
03-01-2012 
Siberian ginseng is a small, woody shrub native to southeastern Russia, northern China, Korea, and Japan. Although Eleutherococcus senticosus is not related to true ginseng (Panax ginseng), the name Siberian ginseng became popular because the two plants shared some similar properties.

Facts and Myths About Fevers in Children

by Erin Psota, ND
02-01-2012 
Fever in children is one of the most common reasons that parents and caregivers seek the advice of healthcare practitioners. As an adaptive immune response against infectious agents, fevers are a beneficial process and a positive indicator of healthy immune function. Because of the risk of serious bacterial illness, it is of utmost importance that naturopathic physicians working with the pediatric population have clear guidelines for treating and referring their pediatric patients.

Lavender Oil for Anxiety and Depression

by Jeremy Appleton, ND
02-01-2012 
Anxiety is a common complaint and may range from every day stress to clinically relevant symptoms requiring medical intervention. Patients with generalized anxiety disorder (GAD) can experience excessive anxiety and worry associated with the stresses of everyday life.

Astaxanthin: A Review of the Literature

by Natural Medicine Journal
02-01-2012 

The Research Behind Vitamin E

by Natural Standard
12-01-2011 
Vitamin E has been proposed for the prevention or treatment of numerous health conditions, often based on its antioxidant properties. Ongoing research is investigating its use in numerous diseases, particularly in cancer and heart disease. Concerns have been raised about the safety of vitamin E supplementation, particularly in high doses. Evidence suggests that regular use of high-dose vitamin E supplements may increase the risk of death from all causes by a small amount, although human research is conflicting.