Peer Reviewed Articles

Citicoline: A Novel Therapeutic Agent with Neuroprotective, Neuromodulatory, and Neuroregenerative Properties

by Irfan Qureshi, ND
06-01-2010 
Citicoline (cytidine diphosphocholine, CDP-choline) is a novel nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. An endogenous compound, citicoline is an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis. It plays several important roles in human physiology, including enhancement of structural integrity and signaling for cell membranes, support of acetylcholine synthesis, and synthesis of betaine, a methyl donor.

The Role of Cortisol in Sleep

by Bradley Bush, ND
06-01-2010 
The hypothalamic-pituitary-adrenal (HPA) axis interacts with sleep in multiple ways. This article reviews the effects of the HPA axis on sleep and the converse. The hormones secreted by the hypothalamus and anterior pituitary that interact with the adrenal cortex are discussed, with implications on sleep disturbances and insomnia. A review of the stages of sleep and sleep architecture is given, and particular attention is paid to the role of cortisol. A dysfunctional HPA and alterations in the rhythm of cortisol production is described as a basis for understanding many cases of insomnia. This abnormal cortisol production and cycling is the basis for the hypothesis and the small body of research on the use of natural therapies to regulate the HPA axis and cortisol production.

L-Carnosine's Effects on Cataract Development

by Tina Kaczor, ND, FABNO
04-01-2010 

Nutritional Protocol for the Treatment of Intestinal Permeability Defects and Related Conditions

by Corey Resnick, ND
03-01-2010 
Under healthy conditions, the intestinal mucosa permits the absorption of vital nutrients from the gut lumen while presenting a barrier against the passage of pathogenic substances into the body. Leaky gut syndrome describes a pathological increase in permeability of the intestinal mucosa that causes increased absorption of intestinally derived endotoxin, antigens, inflammatory mediators, and, in some cases, intact bacteria.

An Overview of Melatonin and Breast Cancer

by Tina Kaczor, ND, FABNO
02-01-2010 

Emotions and Health: Laughter Really Is Good Medicine

by Jacob Schor, ND, FABNO
01-01-2010 

Evaluating the Bioavailability of Isoquercetin

by Jeremy Appleton, ND
01-01-2010 

Natural Depression Remedies

by Rena Freedenberg, ND
12-01-2009 
Depression is a common mental disorder that presents with some or all of the following symptoms: a depressed mood, a loss of interest in things that once brought pleasure, feelings of guilt or low self-worth, disturbed sleep patterns, changes in appetite, a lack of energy, and poor concentration. These symptoms lead to impairments in an individual’s ability to take care of his or her everyday responsibilities and can become chronic or recurrent.

Deglycyrrhizinated Licorice for Gastrointestinal Ulcers

by Tina Kaczor, ND, FABNO
11-01-2009 

Vitamin K and Osteoporosis

by Tina Kaczor, ND, FABNO
09-01-2009 
Vitamin K4, K5 and K6 are all synthetically derived compounds used in experimental settings. In regard to osteoporosis, phylloquinone and menaquinones are the most relevant so this review will address only these vitamers biological significance in the prevention and treatment of osteoporosis.